Mapping the Nanotechnology Landscape in Healthcare: A Multi-Domain Analysis of Scientific Output, Innovation, Clinical Trials, and Market Dynamics

Abstract

Nanotechnology is transforming healthcare by enabling precise molecular-scale manipulation to develop innovative diagnostic and therapeutic solutions. This study integrates bibliometric mapping (2014–2024), patent landscape analysis, clinical trial evaluation, and market forecasting to present a comprehensive view of nano-healthcare. Bibliometric data show a threefold rise in publications (4,321 to 15,081) and a surge in average citations per paper (1.19 to 54.97). Clinical trials of nanoparticle-based therapies expanded fifty-five-fold since 2000, with Phase II studies dominating and oncology comprising over 90% of investigations. Patent filings and grants nearly quadrupled, while median grant-lag times halved post-2018, indicating faster translation. Harmonized market forecasts project growth from USD 232.5 billion in 2024 to USD 493.9 billion by 2030 (CAGR 12.4%), supported by 1,318 catalogued products. A SWOT analysis highlights opportunities in non-oncology applications, regulatory harmonization, and emerging markets, alongside challenges in safety, scalability, and regional disparities, offering a strategic framework for stakeholders to accelerate innovation.